EDUCATION


PhD    Harvard University     November 2007

Single Molecule Studies of Enzymatic Dynamic Fluctuations     Mentor: Xiaoliang Sunney Xie


MA    Harvard University    November 2003


BA    Cornell University    January 2001


Abitur    Simpert-Kraemer-Gymnasium    Krumbach, Bavaria    June 1996



PROFESSIONAL EXPERIENCE

HHMI Janelia Research Campus  Senior Scientist — December 2015  present

HHMI Janelia Research Campus  Research Scientist — January 2015  December 2015

HHMI Janelia Research Campus — Research Specialist — January 2013 – December 2014

Albert Einstein College of Medicine — Postdoctoral Fellow — September 2010  December 2012

Uppsala University — Postdoctoral Fellow — September 2007  August 2010

Harvard University — Graduate Research Fellow — October 2001  August 2007

Harold A. Scheraga Laboratory — Research Technicia— January 2001 – August 2001

Cornell University — Chemistry Major September 1997 – December 2000

Fachklinik Ichenhausen — Patient Care Assistant August 1996 – July 1997


HONORS

2015 AAAS Newcomb Cleveland Prize  —  February 2016

Estonian Science Foundation PUT37 Grant, co-applicant with Dr. Vasili Hauryliuk  —  August 2012

Postdoctoral Representative to the Einstein Senate  —  October 2010 – December 2012

Human Frontier Science Program Cross Disciplinary Fellow  —  June 2008 – August 2011

Young Researcher Participant of the Nobel Laureates Meeting in Lindau  —  June 2009

Swedish Research Council Postdoctoral Fellowship  —  January 2008 – May 2008

Student-nominated Fieser Speaker, Harvard Chemistry  —  April 2007

National Institute of Health Training Grant  —  January 2002 – July 2005

Eli Lilly Poster Presentation Award, 19th Annual Symposium of the Protein Society  —  August 2005

George C. Caldwell Prize, Cornell University, Department of Chemistry, Ithaca, NY  — October 2001

Phi Beta Kappa Honors Society  —  May 2001

Bachelor of Arts with Distinction in all Fields (3.96 Cumulative GPA), Ithaca, NY  —  January 2001

2000 Undergraduate Award in Analytical Chemistry, American Chemical Society  —  October 2000


ACTIVITIES

Administrative Assistant and Photographer, The BackPack Gallery  —  April 2010 – present

INVITED SEMINARS


UT Southwestern  —  Computational & Systems Biology Seminar Series  —  November 2017
Multiplexed Single-molecule Live-cell Imaging Reveals the Dynamic Nature of Complex Biological Reactions (pdf)

Massachusetts Institute of Technology  —  Biophysics Seminar  —  November 2013
Insights into translation by simultaneous single particle tracking of ribosomes and mRNAs

Umeå University  —  International Seminar Series  —  October 2013
Insights into mRNA translation by simultaneous tracking of ribosomes and mRNAs, and by imaging of cytoskeletal structures in live cells

Duke University  —  Joint Biology and Chemistry Seminar  —  April 2013
Mechanistic insights from single molecule tracking of individual enzymes, ribosomes and mRNAs in bacteria and mammalian cells

University of Tartu  —  Biomedical Technology Seminar  —  November 2012
Simultaneous single molecule tracking of β-actin mRNA and the ribosome

University of Munich (LMU)  —  Gene Center Seminar  —  October 2012
Single molecule investigations into β-actin mRNA localization and compartmentalization

University of Munich (LMU)  —  Invited SFB 594 Seminar  —  November 2011
Live-cell imaging and single molecule tracking in bacteria and mammalian cells with laser feedback interference and fluorescence microscopy

TU Delft  —  Applied Physics Seminar  —  April 2009
Stringent Response - From the Test-Tube to Living Cell

University of Tartu  —  Biomedical Technology Seminar  —  December 2008
Single Molecule Approach to Enzymology - From the Test-Tube to Living Bacterial Cells

Harvard University  —  Student-nominated Fieser Lecture  —  April 2007
Fluctuating Single Molecules – Zooming in on Enzyme Kinetics

Georgia Institute of Technology  —  Molecular Biophysics Seminar  —  April 2007
Fluctuating Single Enzyme Molecules

Dickinson College  —  Invited Physics Colloquium  —  October 2006
Biophysics of Single Molecules - Zooming in on Enzyme Kinetics


CONFERENCE LECTURES


4D-Nucleome Annual Meeting, North Bethesda  —  September 2017
Imaging of Multiple Single-Molecules Reveals the Dynamic Nature of Complex Biological Reactions 

10th Berlin Summer Meeting, Computational and Experimental Molecular Biology, Germany  —  June 2017
Simultaneous Live-Cell Imaging of Multiple Single-Molecules Reveals the Dynamic Nature of Complex Biological Reactions 

60th Annual Meeting of the Biophysical Society, Los Angeles, CA  —  February 2016
Simultaneous High-Speed Tracking of Multiple Single-Molecules Reveals Functional Interactions in Living Cells (abstract)

Transcription Imaging Consortium Meeting, HHMI Janelia, Ashburn, VA  —  September 2015
Tracking multiple single molecules in living cells reveals functional interactions

SPIE Optics + Photonics, San Diego, CA  —  August 2015
A three-camera imaging microscope for high-speed single-molecule tracking and super-resolution imaging in living cells 

8th Berlin Summer Meeting, Computational and Experimental Molecular Biology, Germany  —  June 2015
A three-camera imaging microscope for high-speed single-molecule tracking: Insights into translation by co-movement analysis of ribosomes and mRNAs, and by and super-resolution imaging of cytoskeletal structures in living cells

Transcription Imaging Consortium Meeting, HHMI Janelia, Ashburn, VA  —  October 2014
A three-color live cell microscope for fast and accurate tracking of multiple interacting molecules

EMBO | EMBL Symposium: Seeing is Believing, Heidelberg, Germany  —  October 2013
Insights into mRNA compartmentalization and translation by simultaneous single particle tracking of ribosomes and mRNAs, and by super-resolution imaging of cytoskeletal structures in live cells 

Transcription Imaging Consortium Meeting, Janelia Farm, Ashburn, VA  —  September 2012
Positively alarming: mechanistic insights from single particle tracking in a living cell


Ninth HFSP Awardees Meeting and 20th Anniversary Celebration,Tokyo, Japan  —  June 2009
Single Molecule Approach to Stringent Response in Individual Living Bacterial Cells

232nd American Chemical Society National Meeting, San Francisco, CA  —  September 2006
Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited

40th IUPAC World Chemistry Congress, Beijing, China  —  August 2005
From single molecule enzymology to imaging gene expression in live cells, one molecule at a time


CONFERENCE PRESENTATIONS

Focus on Microscopy 2011, Konstanz, Germany  —  April 2011
Single Molecule Investigations of the Stringent Response Machinery in Living Bacterial Cells

4th Mechanobiology Workshop – Biophysical Society Meeting, Singapore  —  November 2010
Imaging Adhesions with Phase-Shifted Laser Feedback Interference Microscopy

10th HFSP Awardees Meeting, Thiruvananthapuram, India  —  November 2010
Stroboscopic Single-molecule Tracking of Freely Diffusing Cytoplasmic Proteins in Living Cells

54th Annual Meeting of the Biophysical Society, San Francisco, CA  —  February 2010
Single Molecule Tracking Inside Individual Living Bacterial Cells

Wallenberg Consortium North Symposium on Modeling and Systems Biology, Stockholm, Sweden  —September 2009  Single Molecule Tracking Inside Living Cells

Ninth International Conference on Systems Biology, Göteborg, Sweden  —  August 2008
A Single Molecule Approach to Stringent Response in Individual Living Bacterial Cells

19th Symposium of the Protein Society, Boston, MA  —  July 2005
A Michaelis-Menten Study of Individual Beta-Galactosidases

228th American Chemical Society National Meeting, Philadelphia, PA  —  August 2004
Enzymatic dynamics of individual Beta-Galactosidases

17th Symposium of the Protein Society, Boston, MA  —  July 2003
Single-molecule Enzymatic Dynamics Probed by Fluorescent-product Detection


TEACHING FELLOW
, HARVARD UNIVERSITY

Frontiers in Molecular Biophysics   —  Fall term, 2003

Principles of Chemistry  —  Spring term, 2002

Honors Introductory Chemistry  —  Fall term, 2001

COMPLETED RESEARCH SUPPORT


PUT37 (co-applicant, PI: Vasili Hauryliuk)    01/01/2013 – 12/31/2015

Estonian Science Foundation (ETF)

ppGpp-mediated activation of RSH proteins: from the mechanism of allosteric regulation to computational properties of the stringent response system

Cross Disciplinary Fellow (LT00829/2008, PI: English, Brian P)    06/01/2008 – 08/31/2011

International Human Frontier Science Program (HFSP)  

Transcription factor dynamics in living bacterial cells at the single cell level



Postdoctoral Fellowship (623-2007-8116, PI: English, Brian P)    01/01/2008 – 05/31/2008

Swedish Research Council (VR)

The Dynamics of Gene Regulation  The Study of Individual Transcription Factor Molecules in Living Cells


Molecular, Cellular and Chemical Biology NIH Training Grant (5 T32 GM07598)   01/01/2002 – 08/31/2005

National Institutes of Health Graduate Research Training Fellowship, Harvard University




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